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In 21 untreated and 7 treated patients with sprue and 12 normal persons the average daily urinary excretion of folic acid was found to be 2.0 ± 0.9, 3.4 ± 1.5 and 5.6 ± 1.4 micrograms, respectively. The difference between the average amounts excreted by the sprue patients and the control group is statistically significant.
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