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The Production of Immunological Unresponsiveness in the Chicken to Produce a Species Specific Antiserum to Bird Serum^*

Antibody production to whole blood serum can be inhibited by injecting neonatal animals with whole serum and maintaining the presence of antigen during the course of the experiment. The frequency of "maintenance" injections is important.

A serum pool should be made at the start of the experiment and used for the "maintenance" injections during the course of the study. In the 12- and 22-week-old experimental birds of two experiments, there was a depression in the amount of antibody produced to the challenging serum. This method produces species specific antisera in high enough titer and with good enough flocculative characteristics for use in the study of arthropod blood meals.

^* This investigation was supported in part by a research grant (E3028C-2) from the National Institute of Allergy and Infectious Diseases of the National Institutes of Health, U.S. Department of Health, Education and Welfare.