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Am. J. Trop. Med. Hyg., 10(6), 1961, pp. 849-854
Copyright © 1961 by The American Society of Tropical Medicine and Hygiene

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The Effect of Prednisone on Persistent Microfilaremia during Treatment with Diethylcarbamazine

F. D. Schofield AND R. E. Rowley
Department of Public Health, Territory of Papua and New Guinea

Prednisone in ordinary dosage has been found to increase significantly the number of Wuchereria bancrofti microfilariae that persist in the night blood during treatment with diethylcarbamazine. This effect ceases when the prednisone is discontinued. The implications of this on theories concerning host-parasite relationships in filariasis and the microfilaricidal action of diethylcarbamazine are discussed.




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