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The Prophylactic Effect of Topically Applied Cedarwood Oil on Infection with Schistosoma mansoni in Mice^*

Mice maintained for 1 week on a bedding of cedarwood shavings were refractory to Schistosoma mansoni infection when exposed by immersing their tails in a cercarial suspension.

Immersion of the tail in ether solutions containing 1% cedarwood oil completely prevented infection in mice exposed 4 hours later. A 50% solution of cedarwood oil in ether provided complete protection for 3 days. The prophylactic efficacy of a 20% cedarwood solution (in ether) was not impaired by washing the treated skin in running water for 4 hours.

East Indian sandalwood oil, clove oil and pineneedle oil have also been shown to possess prophylactic efficacy against S. mansoni.

^* Presented at the annual meeting of the American Society of Tropical Medicine and Hygiene held in Los Angeles, November, 1960.

This article has been cited by other articles:

				W. B. Mors, M. F. dos Santos Fo., H. J. Monteiro, B. Gilbert, and J. Pellegrino Chemoprophylactic Agent in Schistosomiasis: 14,15-Epoxygeranylgeraniol Science, August 25, 1967; 157(3791): 950 - 951. [Abstract] [PDF]