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Am. J. Trop. Med. Hyg., 10(5), 1961, pp. 689-693
Copyright © 1961 by The American Society of Tropical Medicine and Hygiene

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Amodiaquine and Hydroxychloroquine Resistance in Plasmodium falciparum

Martin D. Young*
Department of Health, Education, and Welfare, Public Health Service, National Institute of Allergy and Infectious Diseases, Laboratory of Parasite Chemotherapy, Section on Epidemiology, Columbia, South Carolina

A strain of Plasmodium falciparum from the Magdalena Valley, Colombia, South America, which is resistant to chloroquine, has been shown to be resistant also to amodiaquine (Camoquin®) and to hydroxychloroquine (Plaquenil®), which are other members of the 4-aminoquinoline group. The resistant quality persisted after mosquito passage. The infections responded to quinine and to mepacrine, but relapses occurred. In areas where there is resistance to one of the above 4-aminoquinolines, it would appear unwise to depend upon another of the group for treatment, especially in acute cases; until evidence to the contrary is found, it seems desirable to use some other drug, perhaps quinine or mepacrine.


* Present address: Laboratory of Parasite Chemotherapy, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda 14, Maryland.




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D. C. Warhurst, J. C. P. Steele, I. S. Adagu, J. C. Craig, and C. Cullander
Hydroxychloroquine is much less active than chloroquine against chloroquine-resistant Plasmodium falciparum, in agreement with its physicochemical properties
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P. E. Thompson, A. Bayles, B. Olszewski, and J. A. Waitz
Quinine-Resistant Plasmodium berghei in Mice
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Copyright © 1961 by the American Society of Tropical Medicine and Hygiene.