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Am. J. Trop. Med. Hyg., 10(4), 1961, pp. 541-546
Copyright © 1961 by The American Society of Tropical Medicine and Hygiene

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Enhancement of Stibophen (Fuadin®) Activity against Schistosoma Mansoni in Mice by Feeding Purified Semi-Synthetic Diets

George W. Luttermoser* AND William B. DeWitt{dagger},{ddagger},
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland

The efficacy of stibophen (Fusdin®) for killing mature Schistosoma mansoni was compared in mice on a standard commercial ration and in others on semi-synthetic diets. In several tests in which mice received intraperitoneally a dose of 100 mg/kg daily for 8 days, it was estimated that the drug was from 4 to 16 times more effective in eliminating the schistosomes in the animals on the semi-synthetic diets than in those on the crude commercial ration.


* Laboratory of Parasite Chemotherapy.


{dagger} Laboratory of Parasitic Diseases.


{ddagger} With the technical assistance of R. H. Duvall, O. Kline, and W. Blodgett.






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Copyright © 1961 by the American Society of Tropical Medicine and Hygiene.