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Am. J. Trop. Med. Hyg., 10(4), 1961, pp. 503-509
Copyright © 1961 by The American Society of Tropical Medicine and Hygiene

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N,N'-bis(Dichloroacetyl)Diamines as Amebicidal Agents

D. A. Berberian, R. G. Slighter AND E. W. Dennis
Sterling-Winthrop Research Institute, Rensselaer, New York

The in vitro and in vivo amebicidal activities of eight new synthetic N,N'-bis(dichloroacetyl)diamines are reported. These compounds are amebicidal in vitro against Entamoeba histolytica in concentrations of 1 part in 1 million to as low as 1 part in 50 million. In vivo amebicidal activity was evaluated in hamsters spontaneously infected with Entamoeba criceti. The compounds discussed are highly amebicidal; their calculated ED50 values are in the range of 0.7 to 2.5 mg/kg/day when given for 4 days.






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Copyright © 1961 by the American Society of Tropical Medicine and Hygiene.