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Polypeptides which Affect Smooth Muscles and Blood Vessels

(A Symposium), M. SCHACHTER, M.D., Sc.D., University College, London, Editor. 336 + xv pages, illustrated. New York, Pergamon Press, Inc., 1960. $8.50

This book contains the proceedings of an international symposium held in London in 1959. It is a descendent of a symposium held five years earlier in Montreal that appeared in print under the competent editorship of J. H. Gaddum and bore the title Polypeptides which Stimulate Plain Muscle. The present volume has enlarged its scope as is indicated by the expanded title. It contains 30 papers in 336 pages rather than 15 in 140. This expansion reflects the recent intense investigation of active polypeptides. The structure of a number of these interesting substances is known. They can be characterized as among the most potent biological products known, affecting smooth muscle in concentrations of 10^-10 M or lower. Activities of the neurohypophysial peptides depend on the presence of a pentapeptide ring structure. The angiotensins and bradykinin are straight chains. They all, however, have some similar pharmacological properties and contain 8 to 10 amino acids.