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Immune Response in Rats Infected with Trichinella Spiralis Larvae Subjected to Roentgen Radiation^*

Herman Zaiman, Rudolph G. Howard AND C. Joyce Miller

Two hundred and sixty-six rats divided into 11 groups were used to determine whether the immune response of rats infected with a single dose of 500 irradiated (roentgen ray) Trichinella spiralis larvae varied with the amount of radiation received by the immunising larvae.

The data procured indicated that the immunity produced by the irradiated larvae decreased as the radiation was increased from 8,000 to 20,000 roentgens. It was also noted that larvae exposed to either 8,000 or 12,000 r were more potent immunologic agents than were non-irradiated larvae.

^* This work was supported in part by National Institutes of Health Grant Number E-2612 and American Cancer Society, Inc. Grant Number IN-28A.

The authors are deeply indebted to Justo M. Dias, Dr. Norman Pfeiffer, Dr. Harold Reikes and Robert J. Schulz for assistance in this project and to Mrs. Molly Park for statistical analysis of the data.