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Three months after the initiation of a test project wherein pyrimethaminised salt was distributed among the population in a holoendemic malaria region in Netherlands New Guinea, Plasmodium falciparum appeared to have developed resistance to pyrimethamine. This strain also was found to be cross-resistant to proguanil (Paludrine®).
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T. Mita, K. Tanabe, N. Takahashi, T. Tsukahara, H. Eto, L. Dysoley, H. Ohmae, K. Kita, S. Krudsood, S. Looareesuwan, et al. Independent Evolution of Pyrimethamine Resistance in Plasmodium falciparum Isolates in Melanesia Antimicrob. Agents Chemother., March 1, 2007; 51(3): 1071 - 1077. [Abstract] [Full Text] [PDF] |
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