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Chloramphenicol in Malaria

1. Fifteen patients with typical acute cases of malaria were treated with chloramphenicol by the oral route. In 13 cases Plasmodium vivax was found; in one Plasmodium falciparum was found alone, and two were mixed infections.

2. The dose varied from 50 mg. to 75 mg. per kilogram of body weight per day. Duration of treatment was 8 days in 13 cases, and 6 days and 10 days respectively in the other two. Further observations will be necessary to determine the minimum effective dose.

3. Results were positive in all cases. The number of attacks which occurred after beginning of treatment varied from 0 to 5 with an average of 3.4. The parasites disappeared between the second and tenth day of treatment in the cases with P. vivax. In the infections with P. falciparum only the asexual forms disappeared during this period; the sexual forms persisted and the drug apparently had no action on them.

4. In the subsequent short period of observation there were no relapses, but we cannot say that these patients have been definitely cured.

5. The therapeutic value of chloramphenicol in malaria is markedly inferior to that of other drugs in common use.