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Experimental Study on the Importance of Early Antivenin Treatment in Snake Bite^1,2,

Mice were injected subcutaneously with venoms of Bothrops jararaca or crotalus terrificus and treated with antivenins by intravenous or subcutaneous routes at varying intervals afterwards. The time interval between venom and antivenin injections at which 50 per cent of the animals survived, was 4 minutes if subcutaneous and 215 minutes if intravenous with the Bothrops venom, and 116 minutes if subcutaneous and 319 minutes if intravenous in the case of Crotalus.

¹ This study was carried out under Government of the State of São Paulo (Public Health) Contract Reg. No. TC 3861-50.

² Presented at the Staff Meeting of the Instituto Butantan, July 14, 1951.