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Treatment of Ascariasis in Children with Hetrazan® Syrup¹

One hundred and twenty five Honduran children were treated for ascariasis with 1-diethylcarbamyl-4-methylpiperazine hydrochloride (Hetrazan®) in a syrup which contained 30 mg. of the drug per cc. Of the dosages employed, the most effective was 12 mg. per pound of body weight daily for 4 days; in 80 per cent of 30 cases this amount resulted in absence of ascaris eggs from concentrated (zinc sulfate flotation) stools on both of two post-treatment examinations. Smaller amounts gave less satisfactory results. Eighteen mg. per pound of body weight appeared to be too toxic.

Factors effecting the apparent cure rate are discussed. The most important are the criteria of cure and the season of the year during which the study is done.

It is concluded that when it is undesirable to fast or purge, diethylcarbamazine may be a satisfactory vermifuge. It should be of particular advantage in private practice. However, it is not an ideal compound for mass treatment because multiple doses are necessary.

¹ The Hetrasan® Syrup was supplied by the Lederle Laboratories Division of the American Cyanamid Company.