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An epidemiological investigation revealed that in a district of the Province of Teramo (Abruzzo, Italy), 23.7 per cent of the population showed either active lesions or the scars of oriental sore. Two subsequent annual applications of residual DDT inside houses and stables were sufficient to stop the transmission of the disease. The porportions of new cases in the treated zone were 7 per thousand after the first, and 1.3 per thousand after the second application of DDT, compared with 34.7 and 40.4 per thousand respectively in the untreated zones.
After the first DDT spraying Phlebotomus had disappeared, with an occasional exception, and after the second treatment no Phlebotomus at all was observed either indoors or outside in the treated zone, while these insects continued abundant in the untreated areas.
A special acknowledgement is due to Dr. Marshall Hertig of the Gorgas Memorial Laboratory, Panamá for his kindness in revising the manuscript and for his very helpful suggestions.
1 This work was carried out with funds given by the Italian High Commissariat of Health (ACIS). Dr. Giovanni Rendina of the ACIS was a very active collaborator in both the epidemiological investigations and control work. Facilities and collaboration were also provided by Dr. Amalfitano and Dr. Di Meglio, Provincial Health Officers of Teramo, Dr. Prosperi, Director of the Health Laboratory in Teramo, and Mr. Tamburi of the Health Office in Teramo.
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