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Diasone, Avlosulfon and Sulphetrone as Therapeutic Agents in Experimental Toxoplasmosis^*

Diasone (0.5%) and Avlosulfon (0.1%), when administered in the diet, protect the majority of white mice from death in an otherwise rapidly fatal toxoplasmosis even when therapy is delayed by of the survival time of the untreated animals. Sulphetrone used similarly at 1.5% is without effect and only slightly protective when used at 3.0%. None of the drug controls showed any toxic reactions at these dosages. The carrier condition seems to have been eliminated certainly in 7 and probably in an additional 3 out of the 11 cases investigated. Since our results surpass those previously reported for Diasone and for Avlo-sulfon, it is possible that the method of administration (intermittent dosage following continuous dosage) contributes to the increased effectiveness.

^* Aided by a contract of the Office of Naval Research with the University of Texas.

¹ For reprints address Dr. J. V. Irons, State Health Laboratory, Austin, Texas.