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Biological Antagonism

The Theory of Biological Relativity, by GUSTAV J. MARTIN, Sc.D., Research Director, The National Drug Company, Philadelphia, 516 pages, 64 figures, 44 tables, Philadelphia: The Blakiston Company, 1951. Price, $8.50

Dr. Gustav J. Martin has performed a notable service to biochemists and medicinal chemists in bringing up to date a well organized review of the available information on metabolites and their antagonists. The author has a firm conviction that new medicinal agents can and therefore ought to be conceived rationally from a knowledge of the enzymatic reactions of normal cell metabolites and their selective inhibition by suitable antagonists. That this knowledge should make practical chemotherapy possible rests on two principal premises which the author emphasizes throughout the book:

"The first concerns the relativity of enzyme inhibitors, the selectivity of antimetabolites based upon structures bearing similarity to natural substrates, cofactors, etc. which are normally involved in vital enzymatic transformation. The second is that of the relative concentration of susceptible enzymes in various tissues and the assumption that any given inhibitor will act primarily against that tissue containing a minimum of the enzyme."