AJTMH Transactions of the Royal Society of Tropical Medicine and Hygiene
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Am. J. Trop. Med. Hyg., 1(3), 1952, pp. 470-473
Copyright © 1952 by The American Society of Tropical Medicine and Hygiene

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Arsenamide in the Treatment of Infections with the Periodic Form of the Filaria, Wuchereria Bancrofti*

G. F. Otto, H. W. Brown, S. D. Bell, Jr. AND N. D. Thetford
School of Hygiene and Public Health, Johns Hopkins University, Baltimore, Md.; School of Public Health, Columbia University, and the Department of Health, Christiansted, St. Croix, the Virgin Islands

We have already reported (Thetford et al., 1948) the apparently successful treatment with arsenamide1 of six adult negro males infected with the periodic form of Wuchereria bancrofti in St. Croix, the Virgin Islands. This paper summarizes similar treatment of twelve additional cases in the same area.

These subjects were, as the previous six, all adult male Negroes who had lived all or most of their lives on St. Croix. They were selected because microfilariae had been found in their night blood. Of the twelve, eight were asymptomatic and four (J. G., J. J., R. D., and E. B.) had right scrotal hydroceles but were otherwise asymptomatic. The microfilariae were counted in thick smears made from 0.1 cc. of venous blood drawn between 10 and 12 o'clock at night. Such counts were made before treatment, immediately after the completion of treatment, and periodically thereafter as the patients were available up to a year after treatment.


* This work was supported in part by a contract recommended by the Committee on Medical Research initially between the Office of Scientific Research and Development and the Johns Hopkins University and continued between the Office of the Surgeon General of the U. S. Army and the same university, and in part by a grant from the John and Mary R. Markle Foundation to Columbia University.


1 Arsenamide, generic term for Arsphenamide, p-(bis-[carboxymethyl-mercapto]-arsino)-benzamide.






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Copyright © 1952 by the American Society of Tropical Medicine and Hygiene.