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The Current Status of Physiological Studies on DDT Resistance

Introduction. Insecticide resistance, a development first noticed some fifty years ago (Smith, 1897), is a major problem confronting the medical and economic entomologist today. Realization of this unpleasant fact is growing rapidly (Babers, 1949, 1951), thanks mainly to the conspicuous failure of DDT to provide satisfactory control of flies in some areas where earlier this agent was highly effective. Disconcerting as this situation is, still more so is the experience that empirical attempts at solution of the difficulty have served to emphasize the gravity of the present state of affairs rather than to provide the practical answers sought. Attention has thus been directed anew toward the need for a better understanding of the basic phenomena involved. It is the purpose of this discussion to present a brief evaluation of the physiological data which are now available for application to the problem.