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Diethylcarbamazine (Hetrazan) in Experimental Trichinosis¹

The general acceptance of diethylcarbamazine or Hetrazan (1-diethylcarbamyl-4-methylpiperazine hydrochloride [or dihydrogen citrate]) as a useful drug in the treatment of filarial diseases caused by several types of worm and affecting various animals, including man, has stimulated its trial in treatment of other nematode infections. It has been claimed by Oliver-González, Santiago-Stevenson and Hewitt (1949) and by Etteldorf and Crawford (1950) to be effective in the treatment of infections with Ascaris lumbricoides and by Hewitt, Wallace, White and SubbaRow (1948) to be effective in the removal of ascarids (species not mentioned) from dogs. It was without effect on the tapeworms, hookworms and whipworms of dogs. In reports by van de Erve (1949), and also by Horton (1950), diethylcarbamazine was said to be curative of larva migrans caused by Ancylostoma braziliense in man, but the proof of specific larvicidal action is not evident from these articles.

¹ Read before The American Society of Tropical Medicine, Chicago, Illinois, November 15, 1951.

² Sections of Clinical Pathology and Biochemistry.

³ Fellow in Parasitology.