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Propagation of Dengue Virus Strains in Unweaned Mice¹

1. The New Guinea C and D strains were readily adapted to unweaned mice after a relatively small number of serial intracerebral passages.

2. Work with dengue virus may be greatly facilitated by using unweaned mice rather than older animals for isolation and passage, and, with certain strains, for neutralization tests.

3. The 5 strains of dengue virus studied behaved relatively uniformly in unweaned mice 2–6 days of age but differed sharply in their behavior in mice 3–4 weeks old.

4. Cross-neutralization tests in mice corroborated earlier observations that the New Guinea C and D strains are immunologically different from the Hawaiian and Mochizuki strains.

¹ The initial phases of this study were carried out under the auspices of Naval Medical Research Unit No. 2.

² 1392 University Avenue, Berkeley 2, California.

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