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Experimental Endamoeba Histolytica Infections in Rabbits with Reference to Chemotherapy

Experimental infections of Endamoeba histolytica have been established in several laboratory animals, many of which have been utilized in chemotherapeutic studies. Jones (1948) ably reviewed the history of the infection of dogs, cats, and monkeys with E. histolytica and stated that "such valuable amebicides as stovarsol, carbarsone, Vioform, and Diodoquin have resulted." Anderson et al. (1947, 1950) have further shown the activity of some thioarsenites and antibiotics against natural amebic infection in the monkey. The suitability of the dog as a test animal was studied critically by Thompson et al. (1949, 1950) who reported a satisfactory correlation between the response of canine and human amebiasis and stated that the dog should be particularly useful in the search for new chemotherapeutic agents. Clampit (1948) found that some cases of acute fulminating amebiasis produced experimentally in the kitten were cured by the use of Vioform, chiniofon, and carbarsone but none were cured by emetine.